Numerical Study of the impact of peritoneal fluid and its convection on magnetic nanoparticle hyperthermia in the treatment of peritoneal metastasis

Articles in Press

Document Type : Full Length Research Article

Authors

1 Physics Department, Bu-Ali Sina University

2 Department of Physics, Faculty of Science, Bu-Ali Sina University, Hamadan

3 Cancer Research Center, Hamadan University of Medical Sciences, Hamadan

4 Department of Medical Physics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan

Abstract

Objective: This study evaluates magnetic nanoparticle hyperthermia for treating peritoneal metastasis, focusing on the effect of ascitic fluid and convection on tumor heating and healthy tissue.

Methods: Magnetic nanoparticles (MNPs) were applied to raise tumor temperature to 42–46°C under an alternating magnetic field. Finite element simulations were used to calculate magnetic field distribution (Maxwell’s equations), heat generated by MNPs (Rosensweig model), temperature in the tumor and surrounding solid tissue (Pennes bioheat equation), and fluid temperature and convection in the peritoneal cavity (Navier–Stokes equations).

Results: Induction heating in the tumor was unaffected by ascitic fluid, though overall heat in the peritoneal cavity increased. Heat generated by MNPs was lowest at the tumor center and highest near the surface, with ascitic fluid enhancing heat production. Tumor temperature reached 45–46°C without ascitic fluid but decreased to 43–44°C when convection was present. Healthy tissue temperature remained below 44.2°C in both scenarios. Convective cooling in the fluid was the dominant factor influencing temperature distribution, causing non-uniform heating within the tumor. Conclusion: Magnetic nanoparticle hyperthermia effectively targets tumor tissue while protecting healthy tissue. The presence of ascitic fluid significantly alters temperature distribution through convection, highlighting the importance of considering fluid dynamics in treatment planning.

Keywords

Main Subjects

Journal of Heat and Mass Transfer Research

Articles in Press, Accepted Manuscript
Available Online from 09 May 2026

Files

History

  • Receive Date: 27 April 2025
  • Revise Date: 22 February 2026
  • Accept Date: 09 May 2026

Share

How to cite

Statistics