Numerical Study of the Impact of Peritoneal Fluid and Its Convection on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis

Ranjbaran, Mohadese; Tavakoli, Mohammad Hossein; Keshtpour Amlashi, Zahra; Nikzad, Safoora

doi:10.22075/jhmtr.2026.37513.1732

Numerical Study of the Impact of Peritoneal Fluid and Its Convection on Magnetic Nanoparticle Hyperthermia in the Treatment of Peritoneal Metastasis

Document Type : Full Length Research Article

Authors

Mohadese Ranjbaran ¹

Mohammad Hossein Tavakoli ¹

Zahra Keshtpour Amlashi ²

Safoora Nikzad ³

¹ Department of Physics, Faculty of Science, Bu-Ali Sina University, Hamadan 65174, Iran

² Cancer Research Center, Hamadan University of Medical Sciences, Hamadan 65178, Iran

³ Department of Medical Physics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan 65178, Iran

10.22075/jhmtr.2026.37513.1732

Abstract

This study evaluates magnetic nanoparticle hyperthermia for treating peritoneal metastasis, focusing on the effect of ascitic fluid and convection on tumor heating and healthy tissue. Magnetic nanoparticles (MNPs) were applied to raise tumor temperature to 42–46°C under an alternating magnetic field. Finite element simulations were used to calculate magnetic field distribution (Maxwell’s equations), heat generated by MNPs (Rosensweig model), temperature in the tumor and surrounding solid tissue (Pennes bioheat equation), and fluid temperature and convection in the peritoneal cavity (Navier–Stokes equations). Induction heating in the tumor was unaffected by ascitic fluid, though overall heat in the peritoneal cavity increased. Heat generated by MNPs was lowest at the tumor center and highest near the surface, with ascitic fluid enhancing heat production. Tumor temperature reached 45–46°C without ascitic fluid but decreased to 43–44°C when convection was present. Healthy tissue temperature remained below 44.2°C in both scenarios. Convective cooling in the fluid was the dominant factor influencing temperature distribution, causing non-uniform heating within the tumor. Conclusion: Magnetic nanoparticle hyperthermia effectively targets tumor tissue while protecting healthy tissue. The presence of ascitic fluid significantly alters temperature distribution through convection, highlighting the importance of considering fluid dynamics in treatment planning.

Keywords

Magnetic nanoparticles

Hyperthermia

Peritoneal metastasis

Heat transfer

Fluid modeling

Subjects

Computational Heat transfer

[1] Siegel, R. L., Miller, K.D., Wagle, N.S., Jemal, A., 2023. Cancer statistics. CA: A Cancer Journal for Clinicians, 73(1), pp. 17–48. https://doi.org/10.3322/caac.21763
[2] Sudhakar, A., 2009. History of cancer: ancient and modern treatment methods. Journal of Cancer Science and Therapy, 1, p. 1. doi:10.4172/1948-5956.100000e2
[3] Valastyan, S., Weinberg, R.A., 2011. Tumor metastasis: molecular insights and evolving paradigms. Cell, 147, pp. 275-292. DOI: 10.1016/j.cell.2011.09.024
[4] Noori Daloii, M.R., Fazilati, H., Tabrizi, M., 2013. Cancer metastasis: genetic and microenvironmental factors of distant tissue: a review article. Tehran University Medical Journal, 70, pp.671-683.
[5] Cortés-Guirial, D., Hübner, M., Alyami, M., Bhatt, A., Ceelen, W., Glehen, O., Lordick, F., Ramsay, R., Sgarbura, O., Speeten, K.V., Turaga, K.K., Chand, M., 2021. Primary and metastatic peritoneal surface malignancies. Nature Reviews Disease Primers, 7, p. 91. DOI: 10.1038/s41572-021-00326-6
[6] Coccolini, F., Gheza, F., Lotti, M., Virzi, S., Iusco, D., Ghermandi, C., Melotti, R., Baiocchi, G., Giulini, S.M., Ansaloni, L., Catena, F., 2013. Peritoneal carcinomatosis. World Journal of Gastroenterology, 19(41), pp. 6979-6994. https://doi.org/10.3748/wjg.v19.i41.6979.
[7] Rahman, G.A., Johnson, A.-W.B.R., 2001. Giant omental cyst simulating ascites in a Nigerian child: case report and critique of clinical parameters and investigative modalities. Annals of Tropical Paediatrics, 21, pp. 81-85.
[8] Rao, W., Deng, Z.S., 2010. A review of hyperthermia combined with radiotherapy/chemotherapy on malignant tumors. Critical Reviews in Biomedical Engineering, 38(1), pp. 1-22. doi:10.1615/CritRevBiomedEng.v38. i1.80
[9] Hedayatnasab, Z., Abnisa, F., Wan Daud, W., 2017. Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application. Materials and Design, 123, pp. 174-196. doi: 10.1016/j.matdes.2017.03.036
[10] Darvishi, V., Navidbakhsh, M., Amanpour, S., 2022. Heat and mass transfer in the hyperthermia cancer treatment by magnetic nanoparticles. Heat and Mass Transfer, 58, pp. 1029–1039. doi: 10.1007/s00231-021-03161-3
[11] Peiravi, M., Eslami, H., Ansari, M., Zare-Zardini, H., 2022. Magnetic hyperthermia: Potentials and limitations. Journal of the Indian Chemical Society, 99, pp. 100269. doi: 10.1016/j.jics.2021.100269
[12] Rajan, A., Sahu, N. K., 2020. Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy. Journal of Nanoparticle Research, 22, pp. 319. doi:10.1007/s11051-020-05045-9
[13] Gavilan, H., Avugadda, S. K., Fernandez-Cabada, T., Soni, N., Cassani, M., Mai, B. T., Chantrell, R., Pellegrino, T., 2021. Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer. Chemical Society Reviews, 50, pp.11614–11667. https://doi.org/10.1039/D1CS00427A
[14] Berger, J.M., Preusser, M., Berghoff, A.S., Bergen, E.S., 2023. Malignant ascites: Current therapy options and treatment prospects. Cancer Treatment Reviews, 121, p. 102646. https://doi.org/10.1016/j.ctrv.2023.102646
[15] Sangisetty, S. L., Miner, T. J., 2012. Malignant ascites: A review of prognostic factors, pathophysiology and therapeutic measures. World Journal of Gastrointestinal Surgery, 4, pp. 87-95. doi: 10.4240/wjgs.v4.i4.87
[16] Ikegami, T., Ishiki, H., Kadono, T., Ito, T., Yokomichi, N., 2024. Narrative review of malignant ascites: epidemiology, pathophysiology, assessment, and treatment. Annals of Palliative Medicine, 13. doi: 10.21037/apm-23-554
[17] Bobade, R. S., Yadav, Sh. K., 2017. Lateral forces in the helical compression spring. International Journal for Research in Applied Science & Engineering Technology, 98.
[18] Misron, N., Ying, L. Q., Firdaus, R. N, Abdullah, N., Mailah, N. F, Wakiwaka, H., 2011. Effect of Inductive Coil Shape on Sensing Performance of Linear Displacement Sensor Using Thin Inductive Coil and Pattern Guide. Sensors, 11, pp. 10522-10533. https://doi.org/10.3390/s111110522
[19] Shoshiashvili, L., Shamatava, I., Kakulia, D., Shubitidze, F., 2023. Design and assessment of a novel biconical human-sized alternating magnetic field coil for MNP hyperthermia treatment of deep-seated cancer. Cancers, 15, pp. 1672. doi: 10.3390/cancers15061672
[20] Attaluri, A., Jackowski, J., Sharma, A., Kandala, S. K., Nemkov, V., Yakey, Ch., DeWeese, Th.L., Kumar, A., Goldstein, R. C., 2020. Design and construction of a Maxwell-type induction coil for magnetic nanoparticle hyperthermia. International Journal of Hyperthermia, 37, pp. 1–14. doi: 10.1080/02656736.2019.1704448
[21] Matsumi, Y., Kagawa, T., Yano, S., Tazawa, H., Shigeyasu, K., Takeda, Sh., Ohara, T., Aono, H., Hoffman, R.M., Fujiwara T., Kishimoto, H., 2021. Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model. Cell Cycle, 20, pp. 1122–1133. doi:10.1080/15384101.2021.1919441
[22] Rouni, M.A., Shalev, B., Tsanidis, G., Markakis, I., Kraus, S., Rukenstein, P., Suchi, D., Shalev, O., Samaras, T., 2024. A validated methodological approach to prove the safety of clinical electromagnetic induction systems in magnetic hyperthermia. Cancers, 16, p. 621. doi: 10.3390/cancers16030621
[23] Chia, D.K., Demuytere, J., Ernst, S., Salavati, H., Ceelen, W., 2023. Effects of hyperthermia and hyperthermic intraperitoneal chemoperfusion on the peritoneal and tumor immune contexture. Cancers, 15, p. 4314. doi: 10.3390/cancers15174314
[24] Maraj, E.N., Shah, S. I., Akbar, Sh. N., Muhammad, T., 2023. Thermally progressive Particle-Cu/Blood peristaltic transport with mass transfer in a Non-Uniform Wavy Channel: Closed-form exact solutions. Alexandria Engineering Journal, 74, pp. 453-466 https://doi.org/10.1016/j.aej.2023.05.056
[25] Akbar, Sh. N., Maraj, E.N., Shah, S. I, Muhammad, T., 2024. Nano particle distribution in blood via electroosmotic peristaltic flow in a non-uniform wavy membrane basecapillaries. Sensors and Actuators A: Physical, 376, p. 115626. https://doi.org/10.1016/j.sna.2024.115626
[26] Akbar, Sh. N., Akram, J., Hussain, M. F., Maraj, E.N., Muhammad, T., 2024. Thermal storage study and enhancement of heat transfer through hybrid Jeffrey nanofluid flow in ducts under peristaltic motion with entropy generation.Thermal Science and Engineering Progress, 49, p. 102463. https://doi.org/10.1016/j.tsep.2024.102463
[27] Akram, J., Akbar, Sh. N., Pervaiz, H., Mehmood, R., 2024. Numerical exploration of electroosmotically regulated squeezing rotating flow of TiO2/water nanofluid in a parallel plate channel under triple diffusion convection. Physica Scripta, 99, p. 075249. https://doi.org/10.1088/14024896/ad56d7
[28] Akbar, Sh. N., Akram, J., Hussain, M. F., Maraj, E.N., Muhammad, T., 2024. Hybrid nanofluid flow and heat transfer in symmetric porous ducts with CuO nanoparticles and multi-walled carbon nanotubes under peristaltic motion. Modern Physics Letters BVol., 38, p. 2450333. https://doi.org/10.1142/S0217984924503330
[29] Akbar, Sh. N., Habib, M.B., Rafiq, M., Muhammad, T., Alghamdi, M., 2024. Biological structural study of emerging shaped nanoparticles for the blood flow in diverging tapered stenosed arteries to see their application in drug delivery. Microfluidics and Nanofluidics, 28(40). https://doi.org/10.1007/s10404-024-02735-x
[30] Shokri, A.J., Tavakoli, M. H., Sabouri Dodaran A.A., Akhoundi Khezrabad, M.S., 2016. Numerical study of the influence of coil step on the induction heating process in three-dimensional. Journal of Applied Electromagnetics, 4, pp. 37-44.
[31] Rosensweig, R.E., 2002. Heating magnetic fluid with alternating magnetic field. Journal of Magnetism and Magnetic Materials, 252, pp. 370–374. doi: 10.1016/S0304-8853(02)00706-0
[32] Pennes, H.H., 1948. Analysis of tissue and arterial blood temperatures in the resting human forearm. Journal of Applied Physiology, 1(2), pp. 93-122. doi: 10.1152/jappl.1948.1.2.93
[33] Inman, B.A., Etienne, W., Rubin, R., Owusu, R.A., Oliveira, T.R., Rodriques, D.B., Maccarini, P.F., Stauffer, P.R., Mashal, A., Dewhirst, M.W., 2013. The impact of temperature and urinary constituents on urine viscosity and its relevance to bladder hyperthermia treatment. International Journal Hyperthermia, 29. https://doi.org/10.3109/02656736.2013.775355
[34] Kell Density, G.S., 1975. Thermal expansivity and compressibility of liquid water from 0° to 150°C: correlations and tables for atmospheric pressure and saturation reviewed and expressed on 1968 temperature scale. Journal of Chemical & Engineering Data, 20, pp. 97–105.
[35] Giustini, A. J., Petryk, A. A., Cassim, Sh.M., Tate, J. A., Baker, I., Jack Hoopes, P., 2010. Magnetic nanoparticle hyperthermia in cancer treatment. Nano Life, 1. https://doi.org/10.1142/S1793984410000067
[36] Dürr, S., Janko, C., Lyer, S., Tripal, P., Schwarz, M., Zaloga, J., Tietze, R., Alexiou, C., 2013. Magnetic nanoparticles for cancer therapy. Nanotechnology Reviews, 2, pp. 395–409. https://doi.org/10.1515/ntrev-2013-0011
[37] Rudnev, V., Loveless, D., Cook, R.L., 2017. Handbook of Induction Heating. 2nd ed. CRC Press, Boca Raton.
[38] Stoll, A. M., Greene, L.C., 1959. Relationship between pain and tissue damage due to thermal radiation. Journal of Applied Physiology, 14, pp. 373–382. https://doi.org/10.1152/jappl.1959.14.3.373
[39] Petra Kok, H., Korshuize- van Straten, L., Bakker, A., de Kroon- Oldenhof, R., Geijsen, E.D., Lukas, Stalpers, J.A., Crezee, J., 2017. Online adaptive hyperthermia treatment planning during locoregional heating to suppress treatment-limiting hot spots. International Journal of Radiation Oncology*Biology*Physics, 99, pp. 1039–1047. https://doi.org/10.1016/j.ijrobp.2017.07.011
[40] Schooneveldt, G., Leijsen, Y.V., Balidemaj, E., Crezee, H., 2018. Clinical validation of a novel thermophysical bladder model designed to improve the accuracy of hyperthermia treatment planning in the pelvic region. International Journal of Hyperthermia, 35, pp. 383-397. doi: 10.1080/02656736.2018.1506164